Assay Detail
Functional
CHEMBL912671
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Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.96 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215442 | — | — | 1 | 7.41 |
| CHEMBL439357 | — | — | 1 | 7.32 |
| CHEMBL379203 | — | — | 1 | 7.28 |
| CHEMBL438092 | — | — | 1 | 7.24 |
| CHEMBL132589 | — | — | 1 | 7.22 |
| CHEMBL212943 | — | — | 1 | 6.94 |
| CHEMBL405770 | — | — | 1 | 6.94 |
| CHEMBL132649 | — | — | 1 | 6.27 |
| CHEMBL386580 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215442 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL439357 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL379203 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL438092 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL132589 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL212943 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL405770 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL132649 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL386580 | — | IC50 | = | 930.0 | nM | 6.03 |