Assay Detail
Binding
CHEMBL912696
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Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.76 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215999 | — | — | 1 | 8.96 |
| CHEMBL217758 | — | — | 1 | 8.96 |
| CHEMBL384744 | — | — | 1 | 8.96 |
| CHEMBL215161 | — | — | 1 | 8.92 |
| CHEMBL216016 | — | — | 1 | 8.89 |
| CHEMBL215908 | — | — | 1 | 8.82 |
| CHEMBL214644 | — | — | 1 | 8.77 |
| CHEMBL214128 | — | — | 1 | 8.77 |
| CHEMBL384280 | — | — | 1 | 8.74 |
| CHEMBL214127 | — | — | 1 | 8.74 |
| CHEMBL214179 | — | — | 1 | 8.68 |
| CHEMBL215125 | — | — | 1 | 8.59 |
| CHEMBL214505 | — | — | 1 | 8.57 |
| CHEMBL215387 | — | — | 1 | 8.52 |
| CHEMBL214943 | — | — | 1 | 8.49 |
| CHEMBL214883 | — | — | 1 | 8.49 |
| CHEMBL386384 | — | — | 1 | 8.48 |
| CHEMBL384075 | — | — | 1 | 8.47 |
| CHEMBL215121 | — | — | 1 | 8.39 |
| CHEMBL215025 | — | — | 1 | 8.30 |
| CHEMBL425436 | — | — | 1 | 8.27 |
| CHEMBL217711 | — | — | 1 | 8.21 |
| CHEMBL214675 | — | — | 1 | 8.17 |
| CHEMBL436774 | AR9281 | 2.0 | 1 | 8.15 |
| CHEMBL215069 | — | — | 1 | 8.14 |
| CHEMBL386855 | — | — | 1 | 8.12 |
| CHEMBL215874 | — | — | 1 | 8.06 |
| CHEMBL215827 | — | — | 1 | 8.05 |
| CHEMBL385946 | — | — | 1 | 8.00 |
| CHEMBL387034 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215999 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL384744 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL217758 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL215161 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL216016 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL215908 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL214644 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL214128 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL384280 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL214127 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL214179 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL215125 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL214505 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL215387 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL214883 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL214943 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL386384 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL384075 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL215121 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL215025 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL425436 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL217711 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL214675 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL436774 | AR9281 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL215069 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL386855 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL215874 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL215827 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL385946 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL387034 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL387280 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL215820 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL437328 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL426340 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL215146 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL214884 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL386455 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL385348 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL215356 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL214735 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL386044 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL215168 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL386820 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL214568 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL214534 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL213611 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL216287 | — | IC50 | = | 4200.0 | nM | 5.38 |