Assay Detail
Functional
CHEMBL912820
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Inhibition of CXCL1-induced human neutrophil chemotaxis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.97 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216602 | — | — | 1 | 8.62 |
| CHEMBL254370 | — | — | 1 | 7.32 |
| CHEMBL216981 | NAVARIXIN ANHYDROUS | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216602 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL254370 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL216981 | NAVARIXIN ANHYDROUS | IC50 | < | 1.0 | nM | - |