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Assay Detail

CHEMBL912970

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human KB cell line by methylene blue dye assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Expert

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.
Chang JY, Yang MF, Chang CY, Chen CM, Kuo CC, Liou JP.
J Med Chem (2006) 49 : 6412 -6415
PubMed 17034147 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.34 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 8.82
CHEMBL330407 1 8.15
CHEMBL217041 1 7.85
CHEMBL47426 1 7.80
CHEMBL386803 1 7.57
CHEMBL216956 1 7.36
CHEMBL217139 1 7.30
CHEMBL424885 1 7.13
CHEMBL216433 1 6.81
CHEMBL311636 8Z-3,4',5-TRIMETHOXYSTILBENE 1 6.55
CHEMBL217824 1 5.37
CHEMBL217336 1 -
CHEMBL385699 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 1.5 nM 8.82
CHEMBL330407 IC50 = 7.0 nM 8.15
CHEMBL217041 IC50 = 14.0 nM 7.85
CHEMBL47426 IC50 = 16.0 nM 7.80
CHEMBL386803 IC50 = 27.0 nM 7.57
CHEMBL216956 IC50 = 44.0 nM 7.36
CHEMBL217139 IC50 = 50.0 nM 7.30
CHEMBL424885 IC50 = 74.0 nM 7.13
CHEMBL216433 IC50 = 154.0 nM 6.81
CHEMBL311636 8Z-3,4',5-TRIMETHOXYSTILBENE IC50 = 280.0 nM 6.55
CHEMBL217824 IC50 = 4300.0 nM 5.37
CHEMBL217336 IC50 > 10000.0 nM -
CHEMBL385699 IC50 > 10000.0 nM -