Assay Detail
Functional
CHEMBL913007
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Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Prostate gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.44 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 9.49 |
| CHEMBL25554 | — | — | 1 | 9.18 |
| CHEMBL214986 | — | — | 1 | 7.70 |
| CHEMBL385371 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Kd | = | 0.3236 | nM | 9.49 |
| CHEMBL25554 | — | Kd | = | 0.6607 | nM | 9.18 |
| CHEMBL214986 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL385371 | — | Kd | = | 42.66 | nM | 7.37 |