Assay Detail
Functional
CHEMBL913010
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Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.38 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 6.92 |
| CHEMBL25554 | — | — | 1 | 6.59 |
| CHEMBL214986 | — | — | 1 | 6.34 |
| CHEMBL439346 | — | — | 1 | 6.20 |
| CHEMBL217469 | — | — | 1 | 5.87 |
| CHEMBL385371 | — | — | 1 | - |
| CHEMBL215188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Kd | = | 120.23 | nM | 6.92 |
| CHEMBL25554 | — | Kd | = | 257.04 | nM | 6.59 |
| CHEMBL214986 | — | Kd | = | 457.09 | nM | 6.34 |
| CHEMBL439346 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL217469 | — | Kd | = | 1348.96 | nM | 5.87 |
| CHEMBL385371 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL215188 | — | Kd | > | 10000.0 | nM | - |