Assay Detail
Binding
CHEMBL913147
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Displacement of [3H]colchicine from bovine brain tubulin at 1 uM
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.41 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371795 | — | — | 1 | 4.82 |
| CHEMBL223057 | — | — | 1 | 4.80 |
| CHEMBL227835 | — | — | 1 | 4.72 |
| CHEMBL189355 | — | — | 1 | 4.60 |
| CHEMBL227027 | — | — | 1 | 4.41 |
| CHEMBL227987 | — | — | 1 | 4.22 |
| CHEMBL190320 | — | — | 1 | 4.22 |
| CHEMBL227656 | — | — | 1 | 4.18 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 4.07 |
| CHEMBL387717 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371795 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL223057 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL227835 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL189355 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL227027 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL227987 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL190320 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL227656 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL387717 | — | IC50 | = | 91000.0 | nM | 4.04 |