Assay Detail
Binding
CHEMBL913343
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Inhibition of beta amyloid protein 38 in human H4 cells overexpressing APP695
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.93 | 5.24 |
| IC50 | 1 | 4.11 | 4.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218756 | — | — | 1 | 5.24 |
| CHEMBL219533 | — | — | 1 | 5.09 |
| CHEMBL385554 | — | — | 1 | 5.03 |
| CHEMBL376067 | — | — | 1 | 4.37 |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218756 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL219533 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL385554 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL376067 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1316 | CARPROFEN | IC50 | = | 78000.0 | nM | 4.11 |