Assay Detail
Binding
CHEMBL913345
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Inhibition of beta amyloid protein 42 in human H4 cells overexpressing APP695
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.71 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218756 | — | — | 1 | 5.54 |
| CHEMBL219533 | — | — | 1 | 5.52 |
| CHEMBL375635 | — | — | 1 | 5.16 |
| CHEMBL216929 | — | — | 1 | 5.12 |
| CHEMBL385554 | — | — | 1 | 5.07 |
| CHEMBL216859 | — | — | 1 | 4.96 |
| CHEMBL220307 | — | — | 1 | 4.66 |
| CHEMBL219752 | — | — | 1 | 4.60 |
| CHEMBL216452 | — | — | 1 | 4.43 |
| CHEMBL218912 | — | — | 1 | 4.41 |
| CHEMBL216986 | — | — | 1 | 4.41 |
| CHEMBL219131 | — | — | 1 | 4.40 |
| CHEMBL376067 | — | — | 1 | 4.25 |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 4.12 |
| CHEMBL220131 | — | — | 1 | 4.06 |
| CHEMBL374646 | — | — | 1 | - |
| CHEMBL374782 | — | — | 1 | - |
| CHEMBL216914 | — | — | 1 | - |
| CHEMBL387126 | — | — | 1 | - |
| CHEMBL219425 | — | — | 1 | - |
| CHEMBL219915 | — | — | 1 | - |
| CHEMBL216860 | — | — | 1 | - |
| CHEMBL216918 | — | — | 1 | - |
| CHEMBL219206 | — | — | 1 | - |
| CHEMBL219372 | — | — | 1 | - |
| CHEMBL434753 | — | — | 1 | - |
| CHEMBL375989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218756 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL219533 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL375635 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL216929 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL385554 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL216859 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL220307 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL219752 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL216452 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL218912 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL216986 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL219131 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL376067 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1316 | CARPROFEN | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL220131 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL374646 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL374782 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL216914 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL387126 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL219425 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL219915 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL216860 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL216918 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL219206 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL219372 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL434753 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL375989 | — | IC50 | > | 40000.0 | nM | - |