Assay Detail
Binding
CHEMBL913361
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Inhibition of Electrophorus electricus AChE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.92 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374184 | — | — | 1 | 7.35 |
| CHEMBL219172 | — | — | 1 | 7.28 |
| CHEMBL218940 | — | — | 1 | 7.21 |
| CHEMBL218939 | — | — | 1 | 7.10 |
| CHEMBL219406 | — | — | 1 | 7.04 |
| CHEMBL220294 | — | — | 1 | 6.96 |
| CHEMBL436302 | — | — | 1 | 6.80 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.75 |
| CHEMBL219400 | — | — | 1 | 6.52 |
| CHEMBL219405 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374184 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL219172 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL218940 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL218939 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL219406 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL220294 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL436302 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL95 | TACRINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL219400 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL219405 | — | IC50 | = | 600.0 | nM | 6.22 |