Assay Detail
Binding
CHEMBL913649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.52 | 9.78 |
| Log Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220515 | — | — | 1 | 9.78 |
| CHEMBL301707 | — | — | 1 | 9.44 |
| CHEMBL220221 | — | — | 1 | 9.40 |
| CHEMBL99142 | — | — | 1 | 9.39 |
| CHEMBL222896 | — | — | 1 | 9.08 |
| CHEMBL220781 | — | — | 1 | 8.90 |
| CHEMBL386005 | — | — | 1 | 8.81 |
| CHEMBL220717 | — | — | 1 | 8.13 |
| CHEMBL223289 | — | — | 1 | 7.87 |
| CHEMBL219718 | — | — | 1 | 6.51 |
| CHEMBL219719 | — | — | 1 | 6.36 |
| CHEMBL223842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220515 | — | Ki | = | 0.166 | nM | 9.78 |
| CHEMBL301707 | — | Ki | = | 0.3631 | nM | 9.44 |
| CHEMBL220221 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL99142 | — | Ki | = | 0.4074 | nM | 9.39 |
| CHEMBL222896 | — | Ki | = | 0.8318 | nM | 9.08 |
| CHEMBL220781 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL386005 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL220717 | — | Ki | = | 7.413 | nM | 8.13 |
| CHEMBL223289 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL219718 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL219719 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL223842 | — | Log Ki | - | — | - |