Assay Detail
Functional
CHEMBL913792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human wild type WiDr NTR-ve cells after 18 hrs
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.33 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23216 | — | — | 1 | 4.82 |
| CHEMBL302086 | — | — | 1 | 4.62 |
| CHEMBL223562 | — | — | 1 | 4.55 |
| CHEMBL375143 | — | — | 1 | 4.43 |
| CHEMBL23612 | — | — | 1 | 4.40 |
| CHEMBL222948 | — | — | 1 | 4.40 |
| CHEMBL221322 | — | — | 1 | 4.35 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 4.26 |
| CHEMBL220510 | — | — | 1 | 4.25 |
| CHEMBL45575 | — | — | 1 | 4.21 |
| CHEMBL374264 | — | — | 1 | 4.21 |
| CHEMBL23355 | — | — | 1 | 4.19 |
| CHEMBL220212 | — | — | 1 | 4.17 |
| CHEMBL219981 | — | — | 1 | 4.16 |
| CHEMBL220950 | — | — | 1 | 4.10 |
| CHEMBL223671 | — | — | 1 | 4.10 |
| CHEMBL282488 | — | — | 1 | - |
| CHEMBL306447 | — | — | 1 | - |
| CHEMBL373624 | — | — | 1 | - |
| CHEMBL223101 | — | — | 1 | - |
| CHEMBL222363 | — | — | 1 | - |
| CHEMBL223103 | — | — | 1 | - |
| CHEMBL68861 | — | — | 1 | - |
| CHEMBL376038 | — | — | 1 | - |
| CHEMBL222417 | — | — | 1 | - |
| CHEMBL223346 | — | — | 1 | - |
| CHEMBL220524 | — | — | 1 | - |
| CHEMBL220578 | — | — | 1 | - |
| CHEMBL373629 | — | — | 1 | - |
| CHEMBL223755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23216 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL302086 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL223562 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL375143 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL23612 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL222948 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL221322 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL220510 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL45575 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL374264 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL23355 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL220212 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL219981 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL220950 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL223671 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL281812 | — | IC50 | = | 703000.0 | nM | - |
| CHEMBL374112 | — | IC50 | = | 895000.0 | nM | - |
| CHEMBL426742 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL427414 | — | IC50 | = | 166000.0 | nM | - |
| CHEMBL67870 | — | IC50 | = | 666000.0 | nM | - |
| CHEMBL223461 | — | IC50 | = | 518000.0 | nM | - |
| CHEMBL223561 | — | IC50 | = | 586000.0 | nM | - |
| CHEMBL281563 | — | IC50 | = | 984000.0 | nM | - |
| CHEMBL223404 | — | IC50 | = | 1310000.0 | nM | - |
| CHEMBL304553 | — | IC50 | = | 6390000.0 | nM | - |
| CHEMBL441713 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL426544 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL375396 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL219793 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL220088 | — | IC50 | = | 1230000.0 | nM | - |
| CHEMBL223755 | — | IC50 | = | 194000.0 | nM | - |
| CHEMBL373629 | — | IC50 | = | 804000.0 | nM | - |
| CHEMBL220578 | — | IC50 | = | 437000.0 | nM | - |
| CHEMBL220524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL223346 | — | IC50 | = | 1980000.0 | nM | - |
| CHEMBL222417 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL376038 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL68861 | — | IC50 | = | 243000.0 | nM | - |
| CHEMBL223103 | — | IC50 | = | 6360000.0 | nM | - |
| CHEMBL222363 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL223101 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL373624 | — | IC50 | = | 347000.0 | nM | - |
| CHEMBL306447 | — | IC50 | = | 246000.0 | nM | - |
| CHEMBL282488 | — | IC50 | = | 350000.0 | nM | - |