Assay Detail
Functional
CHEMBL913926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.79 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225575 | — | — | 1 | 9.70 |
| CHEMBL114606 | — | — | 1 | 9.52 |
| CHEMBL425563 | — | — | 1 | 9.30 |
| CHEMBL224005 | — | — | 1 | 9.10 |
| CHEMBL224853 | — | — | 1 | 8.89 |
| CHEMBL389880 | — | — | 1 | 8.89 |
| CHEMBL375488 | — | — | 1 | 8.85 |
| CHEMBL224571 | — | — | 1 | 8.85 |
| CHEMBL224799 | — | — | 1 | 8.62 |
| CHEMBL426191 | — | — | 1 | 8.57 |
| CHEMBL224599 | — | — | 1 | 8.48 |
| CHEMBL224549 | — | — | 1 | 8.23 |
| CHEMBL224800 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225575 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL114606 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL425563 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL224005 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL224853 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL389880 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL375488 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL224571 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL224799 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL426191 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL224599 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL224549 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL224800 | — | EC50 | = | 47.0 | nM | 7.33 |