Assay Detail
Binding
CHEMBL914049
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Inhibition of human kidney NEP at pH 7
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.27 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225085 | — | — | 1 | 8.64 |
| CHEMBL225084 | — | — | 1 | 8.43 |
| CHEMBL224670 | — | — | 1 | 8.34 |
| CHEMBL389061 | — | — | 1 | 8.21 |
| CHEMBL378763 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225085 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL225084 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL224670 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL389061 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL378763 | — | IC50 | = | 18.9 | nM | 7.72 |