Assay Detail
Functional
CHEMBL914103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.58 | 8.89 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 8.89 |
| CHEMBL226612 | — | — | 1 | 8.68 |
| CHEMBL228139 | — | — | 1 | 8.44 |
| CHEMBL227851 | — | — | 1 | 7.57 |
| CHEMBL228138 | — | — | 1 | 7.52 |
| CHEMBL228137 | — | — | 1 | 7.48 |
| CHEMBL228102 | — | — | 1 | 7.24 |
| CHEMBL228103 | — | — | 1 | 7.17 |
| CHEMBL228049 | — | — | 1 | 6.85 |
| CHEMBL227530 | — | — | 1 | 5.92 |
| CHEMBL2368517 | — | — | 1 | - |
| CHEMBL389033 | — | — | 1 | - |
| CHEMBL227852 | — | — | 1 | - |
| CHEMBL227371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL226612 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL228139 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL227851 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL228138 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL228137 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL228102 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL228103 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL228049 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL227530 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2368517 | — | Activity | - | — | - | |
| CHEMBL389033 | — | Activity | - | — | - | |
| CHEMBL227852 | — | Activity | - | — | - | |
| CHEMBL227371 | — | Activity | - | — | - |