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Assay Detail

CHEMBL914129

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli BL21(DE3) beta-lactamase TEM1
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Robin F, Delmas J, Schweitzer C, Tournilhac O, Lesens O, Chanal C, Bonnet R.
Antimicrob Agents Chemother (2007) 51 : 1304 -1309
PubMed 17220412 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 7.56 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL777 CLAVULANIC ACID 4.0 1 7.60
CHEMBL404 TAZOBACTAM 4.0 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL777 CLAVULANIC ACID IC50 = 25.0 nM 7.60
CHEMBL404 TAZOBACTAM IC50 = 30.0 nM 7.52