Assay Detail
Functional
CHEMBL914266
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Inhibition of proliferation of human H460 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.73 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374683 | — | — | 1 | 9.00 |
| CHEMBL374481 | — | — | 1 | 8.52 |
| CHEMBL424759 | — | — | 1 | 8.10 |
| CHEMBL374257 | — | — | 1 | 8.10 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.00 |
| CHEMBL376287 | — | — | 1 | 7.89 |
| CHEMBL221331 | — | — | 1 | 7.85 |
| CHEMBL223703 | — | — | 1 | 7.85 |
| CHEMBL364123 | — | — | 1 | 7.80 |
| CHEMBL223647 | — | — | 1 | 7.54 |
| CHEMBL220945 | — | — | 1 | 6.71 |
| CHEMBL220520 | — | — | 1 | 6.61 |
| CHEMBL220308 | — | — | 1 | 6.55 |
| CHEMBL220210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374683 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL374481 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL424759 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL374257 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL376287 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL221331 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL223703 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL364123 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL223647 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL220945 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL220520 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL220308 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL220210 | — | IC50 | > | 1000.0 | nM | - |