Assay Detail
ADMET
CHEMBL914269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.84 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374257 | — | — | 1 | 9.10 |
| CHEMBL374683 | — | — | 1 | 9.05 |
| CHEMBL374481 | — | — | 1 | 8.64 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374257 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL374683 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL374481 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.7 | nM | 8.57 |