Assay Detail
Binding
CHEMBL914406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MK2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.93 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373598 | — | — | 1 | 6.06 |
| CHEMBL223367 | — | — | 1 | 5.80 |
| CHEMBL223460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373598 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL223367 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL223460 | — | Ki | > | 10000.0 | nM | - |