Assay Detail
Functional
CHEMBL914486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells after 72 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364623 | — | — | 1 | 8.80 |
| CHEMBL424906 | — | — | 1 | - |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | - |
| CHEMBL216240 | — | — | 1 | - |
| CHEMBL386118 | — | — | 1 | - |
| CHEMBL214617 | — | — | 1 | - |
| CHEMBL222036 | — | — | 1 | - |
| CHEMBL217039 | — | — | 1 | - |
| CHEMBL187697 | — | — | 1 | - |
| CHEMBL189649 | — | — | 1 | - |
| CHEMBL273250 | — | — | 1 | - |
| CHEMBL385698 | — | — | 1 | - |
| CHEMBL222218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364623 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL424906 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5416410 | DASATINIB | IC50 | < | 1.0 | nM | - |
| CHEMBL216240 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL386118 | — | IC50 | < | 4.0 | nM | - |
| CHEMBL214617 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL222036 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL217039 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL187697 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL189649 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL273250 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL385698 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL222218 | — | IC50 | < | 2.0 | nM | - |