Assay Detail
Functional
CHEMBL914488
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.63 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385698 | — | — | 1 | 8.51 |
| CHEMBL222218 | — | — | 1 | 8.21 |
| CHEMBL216240 | — | — | 1 | 8.05 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.92 |
| CHEMBL217039 | — | — | 1 | 7.80 |
| CHEMBL214617 | — | — | 1 | 7.64 |
| CHEMBL273250 | — | — | 1 | 7.47 |
| CHEMBL189649 | — | — | 1 | 7.35 |
| CHEMBL222036 | — | — | 1 | 7.33 |
| CHEMBL386118 | — | — | 1 | 6.85 |
| CHEMBL187697 | — | — | 1 | 6.77 |
| CHEMBL424906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385698 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL222218 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL216240 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL217039 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL214617 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL273250 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL189649 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL222036 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL386118 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL187697 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL424906 | — | IC50 | < | 3.0 | nM | - |