Assay Detail
Functional
CHEMBL914489
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Antiproliferative activity against human WiDr cells after 72 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.33 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424906 | — | — | 1 | 8.39 |
| CHEMBL385698 | — | — | 1 | 8.10 |
| CHEMBL222218 | — | — | 1 | 7.64 |
| CHEMBL214617 | — | — | 1 | 7.57 |
| CHEMBL217039 | — | — | 1 | 7.57 |
| CHEMBL273250 | — | — | 1 | 7.50 |
| CHEMBL216240 | — | — | 1 | 7.39 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.28 |
| CHEMBL222036 | — | — | 1 | 6.75 |
| CHEMBL386118 | — | — | 1 | 6.68 |
| CHEMBL187697 | — | — | 1 | 6.57 |
| CHEMBL189649 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424906 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL385698 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL222218 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL214617 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL217039 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL273250 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL216240 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL222036 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL386118 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL187697 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL189649 | — | IC50 | = | 270.0 | nM | 6.57 |