Assay Detail
ADMET
CHEMBL914595
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Cytotoxicity against human KB cells after 72 hrs
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 2: synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.88 | 10.00 |
| Activity | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 10.00 |
| CHEMBL426016 | — | — | 1 | 8.40 |
| CHEMBL224082 | — | — | 1 | 7.30 |
| CHEMBL375041 | — | — | 1 | 7.05 |
| CHEMBL376131 | — | — | 1 | 7.05 |
| CHEMBL224542 | — | — | 1 | 7.00 |
| CHEMBL375887 | — | — | 1 | 6.17 |
| CHEMBL224592 | — | — | 1 | 5.98 |
| CHEMBL388563 | — | — | 1 | 5.96 |
| CHEMBL388562 | — | — | 1 | 5.40 |
| CHEMBL388306 | — | — | 1 | 5.35 |
| CHEMBL426186 | — | — | 1 | - |
| CHEMBL225259 | — | — | 1 | - |
| CHEMBL448780 | — | — | 1 | - |
| CHEMBL387904 | — | — | 1 | - |
| CHEMBL390328 | — | — | 1 | - |
| CHEMBL375713 | — | — | 1 | - |
| CHEMBL413716 | — | — | 1 | - |
| CHEMBL227409 | — | — | 1 | - |
| CHEMBL389420 | — | — | 1 | - |
| CHEMBL414121 | — | — | 1 | - |
| CHEMBL390836 | — | — | 1 | - |
| CHEMBL226922 | — | — | 1 | - |
| CHEMBL376361 | — | — | 1 | - |
| CHEMBL226708 | — | — | 1 | - |
| CHEMBL228101 | — | — | 1 | - |
| CHEMBL376362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL426016 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL224082 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL375041 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL376131 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL224542 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL375887 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL224592 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL388563 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL388562 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL388306 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL426186 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL448780 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL387904 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL390328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375713 | — | Activity | - | — | - | |
| CHEMBL413716 | — | Activity | - | — | - | |
| CHEMBL227409 | — | Activity | - | — | - | |
| CHEMBL389420 | — | Activity | - | — | - | |
| CHEMBL414121 | — | Activity | - | — | - | |
| CHEMBL390836 | — | Activity | - | — | - | |
| CHEMBL226922 | — | Activity | - | — | - | |
| CHEMBL376361 | — | Activity | - | — | - | |
| CHEMBL226708 | — | Activity | - | — | - | |
| CHEMBL228101 | — | Activity | - | — | - | |
| CHEMBL376362 | — | Activity | - | — | - |