Assay Detail
ADMET
CHEMBL914629
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Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.40 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389474 | — | — | 1 | 8.00 |
| CHEMBL227614 | — | — | 1 | 8.00 |
| CHEMBL437539 | — | — | 1 | 8.00 |
| CHEMBL390708 | — | — | 1 | 7.05 |
| CHEMBL225547 | — | — | 1 | 6.89 |
| CHEMBL56640 | — | — | 1 | 6.89 |
| CHEMBL227559 | — | — | 1 | 6.80 |
| CHEMBL413207 | — | — | 1 | 6.70 |
| CHEMBL227616 | — | — | 1 | 6.62 |
| CHEMBL389245 | — | — | 1 | 6.60 |
| CHEMBL267133 | — | — | 1 | 6.60 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.58 |
| CHEMBL387928 | — | — | 1 | 6.50 |
| CHEMBL415383 | — | — | 1 | 6.46 |
| CHEMBL388860 | — | — | 1 | 6.43 |
| CHEMBL415384 | — | — | 1 | 6.41 |
| CHEMBL438111 | — | — | 1 | 6.39 |
| CHEMBL264512 | — | — | 1 | 6.39 |
| CHEMBL387715 | — | — | 1 | 6.34 |
| CHEMBL276292 | — | — | 1 | 6.30 |
| CHEMBL387497 | — | — | 1 | 6.30 |
| CHEMBL389030 | — | — | 1 | 6.25 |
| CHEMBL413206 | — | — | 1 | 6.19 |
| CHEMBL390709 | — | — | 1 | 6.16 |
| CHEMBL225494 | — | — | 1 | 6.14 |
| CHEMBL415382 | — | — | 1 | 6.12 |
| CHEMBL388858 | — | — | 1 | 6.11 |
| CHEMBL389473 | — | — | 1 | 6.07 |
| CHEMBL267776 | — | — | 1 | 6.05 |
| CHEMBL267132 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389474 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL437539 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL227614 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL390708 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL225547 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL56640 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL227559 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL413207 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL227616 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL267133 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL389245 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL387928 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL415383 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL388860 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL415384 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL438111 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL264512 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL387715 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL387497 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL276292 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL389030 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL413206 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL390709 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL225494 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL415382 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL388858 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL389473 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL267776 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL267132 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL266180 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL225654 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL225279 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL390710 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL390711 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL387712 | — | IC50 | = | 5600.0 | nM | 5.25 |