Assay Detail
ADMET
CHEMBL914632
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Cytotoxicity against MOLT4 cells after 72 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.14 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387715 | — | — | 1 | 8.00 |
| CHEMBL413206 | — | — | 1 | 8.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL387928 | — | — | 1 | 7.52 |
| CHEMBL276292 | — | — | 1 | 7.40 |
| CHEMBL225654 | — | — | 1 | 7.22 |
| CHEMBL390711 | — | — | 1 | 7.22 |
| CHEMBL388860 | — | — | 1 | 7.22 |
| CHEMBL225494 | — | — | 1 | 7.22 |
| CHEMBL389030 | — | — | 1 | 7.16 |
| CHEMBL267776 | — | — | 1 | 7.05 |
| CHEMBL225279 | — | — | 1 | 7.00 |
| CHEMBL415382 | — | — | 1 | 6.16 |
| CHEMBL267133 | — | — | 1 | 6.15 |
| CHEMBL415384 | — | — | 1 | 6.15 |
| CHEMBL388858 | — | — | 1 | - |
| CHEMBL413207 | — | — | 1 | - |
| CHEMBL387712 | — | — | 1 | - |
| CHEMBL225547 | — | — | 1 | - |
| CHEMBL390710 | — | — | 1 | - |
| CHEMBL389473 | — | — | 1 | - |
| CHEMBL56640 | — | — | 1 | - |
| CHEMBL227559 | — | — | 1 | - |
| CHEMBL266180 | — | — | 1 | - |
| CHEMBL264512 | — | — | 1 | - |
| CHEMBL267132 | — | — | 1 | - |
| CHEMBL227614 | — | — | 1 | - |
| CHEMBL390709 | — | — | 1 | - |
| CHEMBL415383 | — | — | 1 | - |
| CHEMBL390708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387715 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL413206 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL387928 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL276292 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL225654 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL390711 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL388860 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL225494 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL389030 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL267776 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL225279 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL415382 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL267133 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL415384 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL389245 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL389474 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL437539 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL438111 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL387497 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL227616 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL388858 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL413207 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL387712 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL225547 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL390710 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL389473 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL56640 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL227559 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL266180 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL264512 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL267132 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL227614 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL390709 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL415383 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL390708 | — | IC50 | < | 20.0 | nM | - |