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Assay Detail

CHEMBL914868

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Binding
Inhibition of Src kinase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Proto-oncogene tyrosine-protein kinase Src (CHEMBL267)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.
Boschelli DH, Wu B, Barrios Sosa AC, Durutlic H, Ye F, Raifeld Y, Golas JM, Boschelli F.
J Med Chem (2004) 47 : 6666 -6668
PubMed 15615514 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.83 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL375844 1 7.89
CHEMBL222548 1 7.68
CHEMBL426990 1 7.47
CHEMBL425371 1 7.30
CHEMBL224856 1 6.62
CHEMBL373582 1 6.60
CHEMBL413418 1 6.24
CHEMBL375012 1 6.08
CHEMBL222035 1 5.60
CHEMBL222806 1 -
CHEMBL390943 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL375844 IC50 = 13.0 nM 7.89
CHEMBL222548 IC50 = 21.0 nM 7.68
CHEMBL426990 IC50 = 34.0 nM 7.47
CHEMBL425371 IC50 = 50.0 nM 7.30
CHEMBL224856 IC50 = 240.0 nM 6.62
CHEMBL373582 IC50 = 250.0 nM 6.60
CHEMBL413418 IC50 = 580.0 nM 6.24
CHEMBL375012 IC50 = 830.0 nM 6.08
CHEMBL222035 IC50 = 2500.0 nM 5.60
CHEMBL222806 IC50 > 10000.0 nM -
CHEMBL390943 IC50 > 10000.0 nM -