Assay Detail
Binding
CHEMBL914875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AICAR Tfase
25
Total Activities
24
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional purine biosynthesis protein ATIC (CHEMBL2518) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.02 | 6.22 |
| Activity | 8 | - | - |
| Ki | 1 | 6.81 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375938 | — | — | 2 | 6.81 |
| CHEMBL3144713 | — | — | 1 | 5.48 |
| CHEMBL221733 | — | — | 1 | 5.39 |
| CHEMBL222994 | — | — | 1 | 5.12 |
| CHEMBL222993 | — | — | 1 | 5.11 |
| CHEMBL222808 | — | — | 1 | 5.06 |
| CHEMBL376528 | — | — | 1 | 5.02 |
| CHEMBL222602 | — | — | 1 | 4.94 |
| CHEMBL376026 | — | — | 1 | 4.94 |
| CHEMBL387152 | — | — | 1 | 4.86 |
| CHEMBL221721 | — | — | 1 | 4.77 |
| CHEMBL222654 | — | — | 1 | 4.70 |
| CHEMBL375750 | — | — | 1 | 4.44 |
| CHEMBL225266 | — | — | 1 | 4.26 |
| CHEMBL412516 | — | — | 1 | - |
| CHEMBL222863 | OUABAIN | -1.0 | 1 | - |
| CHEMBL222608 | — | — | 1 | - |
| CHEMBL375406 | — | — | 1 | - |
| CHEMBL222219 | — | — | 1 | - |
| CHEMBL301735 | HOECHST 33258 | — | 1 | - |
| CHEMBL387737 | CUCURBITACIN I | — | 1 | - |
| CHEMBL427248 | — | — | 1 | - |
| CHEMBL222865 | — | — | 1 | - |
| CHEMBL439496 | VERATRIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375938 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL375938 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3144713 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL221733 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL222994 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL222993 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL222808 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL376528 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL376026 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL222602 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL387152 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL221721 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL222654 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL375750 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL225266 | — | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL222865 | — | IC50 | = | 203700.0 | nM | - |
| CHEMBL427248 | — | Activity | - | — | - | |
| CHEMBL387737 | CUCURBITACIN I | Activity | - | — | - | |
| CHEMBL301735 | HOECHST 33258 | Activity | - | — | - | |
| CHEMBL222219 | — | Activity | - | — | - | |
| CHEMBL375406 | — | Activity | - | — | - | |
| CHEMBL222608 | — | Activity | - | — | - | |
| CHEMBL222863 | OUABAIN | Activity | - | — | - | |
| CHEMBL412516 | — | Activity | - | — | - | |
| CHEMBL439496 | VERATRIDINE | IC50 | = | 231300.0 | nM | - |