Assay Detail
Functional
CHEMBL915000
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Antiproliferative activity against MCF7 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.13 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.58 |
| CHEMBL224714 | — | — | 1 | 5.60 |
| CHEMBL223875 | — | — | 1 | 5.55 |
| CHEMBL388527 | — | — | 1 | 5.46 |
| CHEMBL390069 | — | — | 1 | 5.40 |
| CHEMBL224422 | — | — | 1 | 5.35 |
| CHEMBL223547 | — | — | 1 | 5.34 |
| CHEMBL376270 | — | — | 1 | 5.26 |
| CHEMBL224423 | — | — | 1 | 5.26 |
| CHEMBL389004 | — | — | 1 | 5.15 |
| CHEMBL223546 | — | — | 1 | 5.15 |
| CHEMBL224038 | — | — | 1 | 5.07 |
| CHEMBL224029 | — | — | 1 | 5.01 |
| CHEMBL224629 | — | — | 1 | 5.00 |
| CHEMBL224666 | — | — | 1 | 4.89 |
| CHEMBL224171 | — | — | 1 | 4.89 |
| CHEMBL387626 | — | — | 1 | 4.82 |
| CHEMBL389939 | — | — | 1 | 4.80 |
| CHEMBL223498 | — | — | 1 | 4.77 |
| CHEMBL223453 | — | — | 1 | 4.77 |
| CHEMBL224530 | — | — | 1 | 4.70 |
| CHEMBL376317 | — | — | 1 | 4.70 |
| CHEMBL388185 | — | — | 1 | 4.70 |
| CHEMBL224514 | — | — | 1 | 4.60 |
| CHEMBL224758 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL224714 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL223875 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL388527 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL390069 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL224422 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL223547 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL376270 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL224423 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL389004 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL223546 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL224038 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL224029 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL224629 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL224666 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL224171 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL387626 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL389939 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL223498 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL223453 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL224530 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL376317 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL388185 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL224514 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL224758 | — | IC50 | = | 30000.0 | nM | 4.52 |