Assay Detail
Functional
CHEMBL915061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition after 72 hrs of Plasmodium falciparum 3D7 by SYBR green assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Comparison of a SYBR green I-based assay with a histidine-rich protein II enzyme-linked immunosorbent assay for in vitro antimalarial drug efficacy testing and application to clinical isolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.09 | 8.16 |
| IC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588046 | QUININE HYDROCHLORIDE | 1.0 | 2 | 8.16 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 2 | 8.09 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 2 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC90 | = | 26.4 | nM | - |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC90 | = | 29.8 | nM | - |
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC90 | = | 63.7 | nM | - |