Assay Detail
Functional
CHEMBL915062
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Growth inhibition after 72 hrs of Plasmodium falciparum 3D7 by HRPII ELISA
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Comparison of a SYBR green I-based assay with a histidine-rich protein II enzyme-linked immunosorbent assay for in vitro antimalarial drug efficacy testing and application to clinical isolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.14 | 8.23 |
| IC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588046 | QUININE HYDROCHLORIDE | 1.0 | 2 | 8.23 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 2 | 8.12 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 2 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC90 | = | 33.2 | nM | - |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC90 | = | 25.6 | nM | - |
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC90 | = | 42.6 | nM | - |