Assay Detail
Functional
CHEMBL915063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition after 72 hrs of Plasmodium falciparum D6 by SYBR green I assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Comparison of a SYBR green I-based assay with a histidine-rich protein II enzyme-linked immunosorbent assay for in vitro antimalarial drug efficacy testing and application to clinical isolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.19 | 8.21 |
| IC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 2 | 8.21 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 2 | 8.19 |
| CHEMBL588046 | QUININE HYDROCHLORIDE | 1.0 | 2 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC90 | = | 16.1 | nM | - |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC90 | = | 23.3 | nM | - |
| CHEMBL588046 | QUININE HYDROCHLORIDE | IC90 | = | 12.4 | nM | - |