Assay Detail
Binding
CHEMBL915363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plk1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.85 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223367 | — | — | 1 | 6.03 |
| CHEMBL373598 | — | — | 1 | 5.89 |
| CHEMBL223460 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223367 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL373598 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL223460 | — | Ki | = | 2330.0 | nM | 5.63 |