Assay Detail
Functional
CHEMBL915374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against HeLa cells in presence of doxorubicin by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.66 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373897 | — | — | 1 | 6.37 |
| CHEMBL223367 | — | — | 1 | 6.07 |
| CHEMBL223347 | — | — | 1 | 5.92 |
| CHEMBL220035 | — | — | 1 | 5.85 |
| CHEMBL373837 | — | — | 1 | 5.80 |
| CHEMBL375644 | — | — | 1 | 5.72 |
| CHEMBL223460 | — | — | 1 | 5.57 |
| CHEMBL220002 | — | — | 1 | 5.52 |
| CHEMBL413779 | — | — | 1 | 5.52 |
| CHEMBL375097 | — | — | 1 | 5.51 |
| CHEMBL223512 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373897 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL223367 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL223347 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL220035 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL373837 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL375644 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL223460 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL220002 | — | EC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL413779 | — | EC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL375097 | — | EC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL223512 | — | EC50 | = | 37800.0 | nM | 4.42 |