Assay Detail
Functional
CHEMBL915377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Accumulation of H1299 cells in G2/M phase measured as cell cycle arrest by FACS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.12 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373897 | — | — | 1 | 5.12 |
| CHEMBL223512 | — | — | 1 | - |
| CHEMBL375097 | — | — | 1 | - |
| CHEMBL220002 | — | — | 1 | - |
| CHEMBL375644 | — | — | 1 | - |
| CHEMBL413779 | — | — | 1 | - |
| CHEMBL373837 | — | — | 1 | - |
| CHEMBL223347 | — | — | 1 | - |
| CHEMBL223460 | — | — | 1 | - |
| CHEMBL223367 | — | — | 1 | - |
| CHEMBL220035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373897 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL223512 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL375097 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL220002 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL375644 | — | EC50 | - | — | - | |
| CHEMBL413779 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL373837 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL223347 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL223460 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL223367 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL220035 | — | EC50 | > | 10000.0 | nM | - |