Assay Detail
Binding
CHEMBL915383
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Activity at human alpha-1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.67 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113267 | GINKGOLIDE M | — | 1 | 6.19 |
| CHEMBL221821 | GINKGOLIDE C | — | 1 | 5.77 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 5.77 |
| CHEMBL465161 | GINKGOLIDE A | — | 1 | 5.42 |
| CHEMBL374004 | GINKGOLIDE J | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113267 | GINKGOLIDE M | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL221821 | GINKGOLIDE C | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL514432 | GINKOLIDE B | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL465161 | GINKGOLIDE A | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL374004 | GINKGOLIDE J | IC50 | = | 6400.0 | nM | 5.19 |