Assay Detail
Binding
CHEMBL915412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN-35428 from DAT
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.83 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610897 | — | — | 1 | 8.96 |
| CHEMBL311347 | — | — | 1 | 8.89 |
| CHEMBL218082 | — | — | 1 | 8.77 |
| CHEMBL224819 | — | — | 1 | 8.77 |
| CHEMBL312037 | — | — | 1 | 8.77 |
| CHEMBL375889 | — | — | 1 | 8.54 |
| CHEMBL375888 | — | — | 1 | 8.51 |
| CHEMBL373385 | — | — | 1 | 7.99 |
| CHEMBL374712 | — | — | 1 | 7.93 |
| CHEMBL2079586 | — | — | 1 | 7.86 |
| CHEMBL2096859 | — | — | 1 | 7.80 |
| CHEMBL222705 | — | — | 1 | 7.68 |
| CHEMBL83729 | — | — | 1 | 7.64 |
| CHEMBL2096860 | — | — | 1 | 7.64 |
| CHEMBL221993 | — | — | 1 | 7.63 |
| CHEMBL2096858 | — | — | 1 | 7.60 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL376899 | — | — | 1 | 7.00 |
| CHEMBL2096861 | — | — | 1 | 6.68 |
| CHEMBL2096857 | — | — | 1 | 6.49 |
| CHEMBL2096856 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610897 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL311347 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL218082 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL224819 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL312037 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL375889 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL375888 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL373385 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL374712 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL2079586 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2096859 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL222705 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL83729 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2096860 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL221993 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL2096858 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL376899 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2096861 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL2096857 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2096856 | — | IC50 | = | 670.0 | nM | 6.17 |