Assay Detail
Binding
CHEMBL915538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha activated NF-kappaB dependent transactivation of HIV-1 LTR Luc in 5.1 cells
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 5 | - | - |
| IC50 | 2 | 5.18 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225421 | ARZANOL | — | 1 | 5.30 |
| CHEMBL225422 | HELIPYRONE | — | 1 | 5.06 |
| CHEMBL390585 | MICROPYRONE | — | 1 | - |
| CHEMBL224293 | — | — | 1 | - |
| CHEMBL223940 | — | — | 1 | - |
| CHEMBL223939 | — | — | 1 | - |
| CHEMBL390376 | BITALIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225421 | ARZANOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL225422 | HELIPYRONE | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL390585 | MICROPYRONE | Activity | - | — | - | |
| CHEMBL224293 | — | Activity | - | — | - | |
| CHEMBL223940 | — | Activity | - | — | - | |
| CHEMBL223939 | — | Activity | - | — | - | |
| CHEMBL390376 | BITALIN A | Activity | - | — | - |