Assay Detail
Binding
CHEMBL915601
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Inhibition of human recombinant DPP8
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.94 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388111 | — | — | 1 | 6.42 |
| CHEMBL223914 | — | — | 1 | 6.25 |
| CHEMBL223497 | — | — | 1 | 6.17 |
| CHEMBL389244 | — | — | 1 | 6.13 |
| CHEMBL224435 | — | — | 1 | 5.33 |
| CHEMBL390513 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388111 | — | IC50 | = | 378.8 | nM | 6.42 |
| CHEMBL223914 | — | IC50 | = | 562.8 | nM | 6.25 |
| CHEMBL223497 | — | IC50 | = | 678.9 | nM | 6.17 |
| CHEMBL389244 | — | IC50 | = | 736.5 | nM | 6.13 |
| CHEMBL224435 | — | IC50 | = | 4687.0 | nM | 5.33 |
| CHEMBL390513 | — | IC50 | = | 4756.0 | nM | 5.32 |