Assay Detail
Binding
CHEMBL915603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at NET
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 9.00 |
| CHEMBL223166 | — | — | 1 | 8.10 |
| CHEMBL223058 | — | — | 1 | 8.08 |
| CHEMBL426743 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL223166 | — | Ki | = | 7.93 | nM | 8.10 |
| CHEMBL223058 | — | Ki | = | 8.29 | nM | 8.08 |
| CHEMBL426743 | — | Ki | = | 10.8 | nM | 7.97 |