Assay Detail
Binding
CHEMBL915778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymus
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 10.11 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222195 | — | — | 1 | 10.74 |
| CHEMBL220846 | — | — | 1 | 10.51 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.15 |
| CHEMBL375811 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222195 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL220846 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 0.071 | nM | 10.15 |
| CHEMBL375811 | — | EC50 | = | 0.89 | nM | 9.05 |