Assay Detail
ADMET
CHEMBL915913
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Cytotoxicity against pentamidine-resistant Leishmania enriettii LePentR50 by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Leishmania enriettii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.27 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264380 | — | — | 1 | 4.40 |
| CHEMBL28 | APIGENIN | — | 1 | 4.26 |
| CHEMBL267353 | — | — | 1 | 4.16 |
| CHEMBL216170 | — | — | 1 | - |
| CHEMBL217387 | — | — | 1 | - |
| CHEMBL424736 | — | — | 1 | - |
| CHEMBL214738 | — | — | 1 | - |
| CHEMBL215017 | — | — | 1 | - |
| CHEMBL216136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264380 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL28 | APIGENIN | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL267353 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL216170 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL217387 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL424736 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL214738 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL215017 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL216136 | — | IC50 | > | 200000.0 | nM | - |