Assay Detail
ADMET
CHEMBL915932
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Cytotoxicity against human KM12 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KM12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.59 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464670 | — | — | 1 | 6.89 |
| CHEMBL499648 | — | — | 1 | 6.83 |
| CHEMBL540960 | — | — | 1 | 6.11 |
| CHEMBL154716 | — | — | 1 | 6.10 |
| CHEMBL455005 | — | — | 1 | 5.95 |
| CHEMBL464493 | — | — | 1 | 5.76 |
| CHEMBL463639 | — | — | 1 | 5.76 |
| CHEMBL503999 | — | — | 1 | 5.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.10 |
| CHEMBL228210 | — | — | 1 | 5.03 |
| CHEMBL455550 | — | — | 1 | 4.72 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.36 |
| CHEMBL227188 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464670 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL499648 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL540960 | — | IC50 | = | 776.0 | nM | 6.11 |
| CHEMBL154716 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL455005 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL464493 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL463639 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL503999 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL228210 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL455550 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL852 | MELPHALAN | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL227188 | — | IC50 | = | 43700.0 | nM | 4.36 |