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Assay Detail

CHEMBL915933

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ADMET
Cytotoxicity against human SW620 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type SW-620
Confidence 1 — Organism
Curated By Autocuration

Target

SW-620 (CHEMBL612262)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
Das U, Alcorn J, Shrivastav A, Sharma RK, De Clercq E, Balzarini J, Dimmock JR.
Eur J Med Chem (2007) 42 : 71 -80
PubMed 16996657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.70 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464670 1 6.72
CHEMBL463639 1 6.68
CHEMBL499648 1 6.47
CHEMBL540960 1 6.25
CHEMBL154716 1 6.24
CHEMBL455005 1 5.99
CHEMBL464493 1 5.87
CHEMBL503999 1 5.84
CHEMBL455550 1 5.45
CHEMBL228210 1 4.98
CHEMBL185 FLUOROURACIL 4.0 1 4.73
CHEMBL227188 1 4.52
CHEMBL852 MELPHALAN 4.0 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464670 IC50 = 191.0 nM 6.72
CHEMBL463639 IC50 = 209.0 nM 6.68
CHEMBL499648 IC50 = 339.0 nM 6.47
CHEMBL540960 IC50 = 562.0 nM 6.25
CHEMBL154716 IC50 = 575.0 nM 6.24
CHEMBL455005 IC50 = 1020.0 nM 5.99
CHEMBL464493 IC50 = 1350.0 nM 5.87
CHEMBL503999 IC50 = 1450.0 nM 5.84
CHEMBL455550 IC50 = 3550.0 nM 5.45
CHEMBL228210 IC50 = 10500.0 nM 4.98
CHEMBL185 FLUOROURACIL IC50 = 18600.0 nM 4.73
CHEMBL227188 IC50 = 30200.0 nM 4.52
CHEMBL852 MELPHALAN IC50 = 38900.0 nM 4.41