Assay Detail
Binding
CHEMBL915970
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Inhibition of Rho kinase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Design and synthesis of rho kinase inhibitors (III).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.78 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387625 | — | — | 1 | 7.60 |
| CHEMBL375556 | — | — | 1 | 7.19 |
| CHEMBL223815 | — | — | 1 | 7.19 |
| CHEMBL224361 | — | — | 1 | 7.16 |
| CHEMBL387954 | — | — | 1 | 7.12 |
| CHEMBL223336 | — | — | 1 | 7.02 |
| CHEMBL389926 | — | — | 1 | 7.00 |
| CHEMBL224505 | — | — | 1 | 6.85 |
| CHEMBL266512 | — | — | 1 | 6.75 |
| CHEMBL224360 | — | — | 1 | 6.75 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.75 |
| CHEMBL225492 | — | — | 1 | 6.73 |
| CHEMBL375735 | — | — | 1 | 6.71 |
| CHEMBL388285 | — | — | 1 | 6.69 |
| CHEMBL224508 | — | — | 1 | 6.68 |
| CHEMBL375882 | — | — | 1 | 6.68 |
| CHEMBL223907 | — | — | 1 | 6.63 |
| CHEMBL389254 | — | — | 1 | 6.58 |
| CHEMBL375736 | — | — | 1 | 6.57 |
| CHEMBL373759 | — | — | 1 | 6.56 |
| CHEMBL438783 | — | — | 1 | 6.51 |
| CHEMBL224472 | — | — | 1 | 6.46 |
| CHEMBL224362 | — | — | 1 | 6.36 |
| CHEMBL224417 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387625 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL375556 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL223815 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL224361 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL387954 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL223336 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL389926 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL224505 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL266512 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL224360 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL38380 | FASUDIL | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL225492 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL375735 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL388285 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL224508 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL375882 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL223907 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL389254 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL375736 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL373759 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL438783 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL224472 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL224362 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL224417 | — | IC50 | = | 580.0 | nM | 6.24 |