Assay Detail
Functional
CHEMBL915971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of rho kinase inhibitors (III).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.85 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387625 | — | — | 1 | 6.00 |
| CHEMBL387954 | — | — | 1 | 5.00 |
| CHEMBL375556 | — | — | 1 | 4.96 |
| CHEMBL388285 | — | — | 1 | 4.85 |
| CHEMBL223815 | — | — | 1 | 4.85 |
| CHEMBL223907 | — | — | 1 | 4.82 |
| CHEMBL389926 | — | — | 1 | 4.77 |
| CHEMBL373759 | — | — | 1 | 4.70 |
| CHEMBL223336 | — | — | 1 | 4.66 |
| CHEMBL225492 | — | — | 1 | 4.64 |
| CHEMBL438783 | — | — | 1 | 4.52 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387625 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL387954 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL375556 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL388285 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL223815 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL223907 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL389926 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL373759 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL223336 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL225492 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL438783 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL38380 | FASUDIL | IC50 | = | 35000.0 | nM | 4.46 |