Assay Detail
Functional
CHEMBL916137
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antimalarial property of orally active phenoxazinium salts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.51 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390553 | — | — | 1 | 8.62 |
| CHEMBL389921 | — | — | 2 | 8.55 |
| CHEMBL227349 | — | — | 1 | 7.90 |
| CHEMBL538855 | — | — | 1 | 7.55 |
| CHEMBL538854 | — | — | 1 | 6.70 |
| CHEMBL538601 | — | — | 1 | 6.57 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390553 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL389921 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL389921 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL227349 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL538855 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL538854 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL538601 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 1500.0 | nM | 5.82 |