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Assay Detail

CHEMBL916294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Activity at NMDA receptor in rat corticle slice assessed as antagonism of 10 uM NMDA-induced response
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.
Conti P, De Amici M, Grazioso G, Roda G, Barberis Negra FF, Nielsen B, Stensbøl TB, Madsen U, Bräuner-Osborne H, Frydenvang K, De Sarro G, Toma L, De Micheli C.
J Med Chem (2004) 47 : 6740 -6748
PubMed 15615523 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.85 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL370566 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL370566 IC50 = 14200.0 nM 4.85