Assay Detail
Functional
CHEMBL916322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ErbB4 tyrosine kinase phosphorylation expressed in human CEM/4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM/4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-4 (CHEMBL3009) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.28 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204168 | — | — | 1 | 7.31 |
| CHEMBL1204199 | — | — | 1 | 7.30 |
| CHEMBL1204262 | — | — | 1 | 7.23 |
| CHEMBL1203937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204168 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1204199 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1204262 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1203937 | — | IC50 | > | 100.0 | nM | - |