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Assay Detail

CHEMBL916350

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effect on modulating pentamidine-resistance of Leishmania enriettii LePentR50 assessed as decrease in survival after 72 hrs by MTS
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.
Wong IL, Chan KF, Burkett BA, Zhao Y, Chai Y, Sun H, Chan TH, Chow LM.
Antimicrob Agents Chemother (2007) 51 : 930 -940
PubMed 17194831 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.88 6.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL214738 1 6.03
CHEMBL215017 1 5.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL214738 EC50 = 940.0 nM 6.03
CHEMBL215017 EC50 = 1850.0 nM 5.73