Assay Detail
Functional
CHEMBL916387
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Growth inhibition of human PC3 cells after 6 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.46 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190837 | — | — | 1 | 5.82 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.70 |
| CHEMBL7301 | FENRETINIDE | 3.0 | 1 | 5.44 |
| CHEMBL223072 | — | — | 1 | 5.24 |
| CHEMBL57765 | — | — | 1 | 5.11 |
| CHEMBL224828 | — | — | 1 | - |
| CHEMBL388064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190837 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL38 | TRETINOIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7301 | FENRETINIDE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL223072 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL57765 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL224828 | — | IC50 | - | — | - | |
| CHEMBL388064 | — | IC50 | - | — | - |